A powerful product with two different modes of action for controlling downy mildew, blight, and a wide range of fungal diseases. On this page, we review its mechanism of action, applications, safety tips, and environmental considerations.
The combination fungicide Dimethomorph + Pyraclostrobin is an advanced and widely used product in agriculture. By combining two active ingredients with different modes of action, it serves as a systemic, protective, and curative fungicide for controlling multiple fungal diseases.
This fungicide is available as a water-dispersible granule (DF), containing approximately 12% Dimethomorph and 6.7% Pyraclostrobin, and is marketed domestically and internationally under names such as Cabrio Duo.
Mechanism of Action
Dimethomorph is an inhibitor of cinnamic acid amide activity, which disrupts the synthesis of phospholipids in the fungal cell wall. This disruption stops mycelial growth and prevents spore and zoospore germination. Dimethomorph is highly effective against Oomycete fungi, including pathogens from the Peronosporaceae family and some Phytophthora species.
Pyraclostrobin, a member of the strobilurin family, blocks electron transport in mitochondrial Complex III (cytochrome bc1), preventing ATP production and halting fungal energy production. It has fungicidal, protective, and curative properties and is quickly absorbed and translocated within the plant.
The combination of these two active ingredients provides a strong synergistic effect due to their completely different mechanisms, resulting in better disease control and reduced risk of resistance development in pathogenic fungi.
Uses
Tomato, potato, and other vegetables: Alternaria leaf spot (early blight)
Cucurbits, wheat, and barley: Diseases caused by Oomycetes, such as downy mildew
Pistachio and stone fruits: Alternaria
Other crops: Fungal diseases of leaves, stems, and fruits in field and orchard crops
Application Guidelines:
Spray before symptoms appear or at early infection for optimal effectiveness.
Spraying interval is usually 10–14 days; do not exceed 3 applications per season.
Pre-harvest interval depends on the crop (3–14 days).
Product
Diseases
Consumption rate
Cucumber
Downy mildew
250 g per 1000 L of water
Additional information
Weight
250gr
Formulation
DF18.7%
Resistance group
FRAC=11,C3,FRAC=40,H5
Chemical group
Cinamic acid amides, Strobilurins
Amount of active ingredient
187gr/Kg
Use mask, gloves, goggles, and protective clothing during spraying.
Avoid contact with skin and eyes.
Do not spray in windy conditions to prevent off-target drift.
Protective equipment is mandatory during application.
Prevent the chemical from entering water sources to protect the environment.
Rotate fungicides to prevent resistance.
Use cautiously during flowering to protect bees.
Pyraclostrobin is toxic to aquatic life; avoid runoff into water bodies.
Dimethomorph is moderately biodegradable in soil with low mobility.
Dispose of empty containers properly; do not release into the environment.
Maintain buffer zones from water sources to protect ecosystems.
